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Pentose Phosphate Pathway Function Affects Tolerance to the G-Quadruplex Binder TMPyP4
G-quadruplexes form in guanine-rich regions of DNA and the presence of these structures at telomeres prevents the activity of telomerase in vitro. Ligands such as the cationic porphyrin TMPyP4 stabilise G-quadruplexes and are therefore under investigation for their potential use as anti-cancer drugs...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3680382/ https://ncbi.nlm.nih.gov/pubmed/23776642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066242 |
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