Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4

Replication protein A (RPA) plays an essential role in DNA replication by binding and unfolding non-canonical single-stranded DNA (ssDNA) structures. Of the six RPA ssDNA binding domains (labeled A-F), RPA-CDE selectively binds a G-quadruplex forming sequence (5′-TAGGGGAAGGGTTGGAGTGGGTT-3′ called Gq...

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Autores principales: Prakash, Aishwarya, Kieken, Fabien, Marky, Luis A., Borgstahl, Gloria E. O.
Formato: Artigo
Lenguaje:Inglês
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136172/
https://ncbi.nlm.nih.gov/pubmed/21772995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/529828
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