Design and Synthesis of Neuroprotective Methylthiazoles and Modification as NO-Chimeras for Neurodegenerative Therapy

Learning and memory deficits in Alzheimer’s disease (AD) result from synaptic failure and neuronal loss, the latter caused in part by excitotoxicity and oxidative stress. A therapeutic approach is described, which uses NO-chimeras directed at restoration of both synaptic function and neuroprotection...

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Bibliographische Detailangaben
Hauptverfasser: Qin, Zhihui, Luo, Jia, VandeVrede, Lawren, Tavassoli, Ehsan, Fa’, Mauro, Teich, Andrew, Arancio, Ottavio, Thatcher, Gregory R. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680370/
https://ncbi.nlm.nih.gov/pubmed/22779770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300353r
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