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Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells

BACKGROUND: Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, me...

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Hlavní autoři: Chang, Alex Y, Wang, Miao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680296/
https://ncbi.nlm.nih.gov/pubmed/23721490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-267
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