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Molecular mechanisms of action and potential biomarkers of growth inhibition of dasatinib (BMS-354825) on hepatocellular carcinoma cells

BACKGROUND: Molecular targeted therapy has emerged as a promising treatment of Hepatocellular carcinoma (HCC). One potential target is the Src family Kinase (SFK). C-Src, a non-receptor tyrosine kinase is a critical link of multiple signal pathways that regulate proliferation, invasion, survival, me...

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Detalhes bibliográficos
Main Authors: Chang, Alex Y, Wang, Miao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680296/
https://ncbi.nlm.nih.gov/pubmed/23721490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-267
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