Negative Feedback Enhances Robustness in the Yeast Polarity Establishment Circuit

Many cells undergo symmetry-breaking polarization toward a randomly oriented “front” in the absence of spatial cues. In budding yeast, such polarization involves a positive feedback loop that enables amplification of stochastically arising clusters of polarity factors. Previous mathematical modeling...

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Main Authors: Howell, Audrey S., Jin, Meng, Wu, Chi-Fang, Zyla, Trevin R., Elston, Timothy C., Lew, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680131/
https://ncbi.nlm.nih.gov/pubmed/22500799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.012
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