Effects of a glucokinase activator on hepatic intermediary metabolism: study with (13)C-isotopomer-based metabolomics

GKAs (glucokinase activators) are promising agents for the therapy of Type 2 diabetes, but little is known about their effects on hepatic intermediary metabolism. We monitored the fate of (13)C-labelled glucose in both a liver perfusion system and isolated hepatocytes. MS and NMR spectroscopy were d...

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Bibliographic Details
Main Authors: Nissim, Itzhak, Horyn, Oksana, Nissim, Ilana, Daikhin, Yevgeny, Wehrli, Suzanne L., Yudkoff, Marc, Matschinsky, Franz M.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679927/
https://ncbi.nlm.nih.gov/pubmed/22448977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120163
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