NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: candidate electrostatic interactions and microdomain formation

We report the NMR solution structure of a synthetic 40-mer (T(377)-E(416)) that encompasses human cannabinoid receptor-1 (hCB1) transmembrane helix 7 (TMH7) and helix 8 (H8) [hCB1(TMH7/H8)] in 30% trifluoroethanol/H(2)O. Structural features include, from the peptide’s amino terminus, a hydrophobic α...

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Autores principales: Tyukhtenko, Sergiy, Tiburu, Elvis K, Deshmukh, Lalit, Vinogradova, Olga, Janero, David R., Makriyannis, Alexandros
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679914/
https://ncbi.nlm.nih.gov/pubmed/19766594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.09.053
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