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Negative regulation of p53 by Ras superfamily protein RBEL1A

We had previously reported that RBEL1A, a novel Ras-like GTPase, was overexpressed in multiple human malignancies and that its depletion suppressed cell growth. However, the underlying molecular mechanism remained to be elucidated. Here we report that depletion of endogenous RBEL1A results in p53 ac...

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Hlavní autoři: Lui, Ki, An, Jie, Montalbano, JoAnne, Shi, Jingxue, Corcoran, Chad, He, Qin, Sun, Hong, Sheikh, M. Saeed, Huang, Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679486/
https://ncbi.nlm.nih.gov/pubmed/23572512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.118117
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