Structural Definition Is Important for the Propagation of the Yeast [PSI(+)] Prion

Prions are propagated in Saccharomyces cerevisiae with remarkable efficiency, yet we know little about the structural basis of sequence variations in the prion protein that support or prohibit propagation of the prion conformation. We show that certain single-amino-acid substitutions in the prion pr...

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Bibliographic Details
Main Authors: Marchante, Ricardo, Rowe, Michelle, Zenthon, Jo, Howard, Mark J., Tuite, Mick F.
Format: Artigo
Language:Inglês
Published: Cell Press 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679450/
https://ncbi.nlm.nih.gov/pubmed/23746351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.010
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