B Lymphocyte “Original Sin” in the Bone Marrow Enhances Islet Autoreactivity in Type 1 Diabetes-Prone NOD mice(,,3)

Effective central tolerance is required to control the large extent of autoreactivity normally present in the developing B cell repertoire. Insulin-reactive B cells are required for T1D in the NOD mouse, as engineered mice lacking this population are protected from disease. The VH125Tg model is used...

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Autors principals: Henry-Bonami, Rachel A., Williams, Jonathan M., Rachakonda, Amita B., Karamali, Mariam, Kendall, Peggy L., Thomas, James W.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679359/
https://ncbi.nlm.nih.gov/pubmed/23677466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201359
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