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Recent thymic emigrants and mature naïve T cells exhibit differential DNA methylation at key cytokine loci

Recent thymic emigrants (RTEs) are the youngest T cells in the lymphoid periphery, and exhibit phenotypic and functional characteristics distinct from those of their more mature counterparts in the naïve peripheral T cell pool. We show here that the Il2 and Il4 promoter regions of naïve CD4(+) RTEs...

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Detalhes bibliográficos
Main Authors: Berkley, Amy M., Hendricks, Deborah W., Simmons, Kalynn B., Fink, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679312/
https://ncbi.nlm.nih.gov/pubmed/23686491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300181
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