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Resistance Mutations outside the Integrase Coding Region Have an Effect on Human Immunodeficiency Virus Replicative Fitness but Do Not Affect Its Susceptibility to Integrase Strand Transfer Inhibitors

Most studies describing phenotypic resistance to integrase strand transfer inhibitors have analyzed viruses carrying only patient-derived HIV-1 integrase genes (INT-recombinant viruses). However, to date, many of the patients on INSTI-based treatment regimes, such as raltegravir (RAL), elvitegravir...

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Hlavní autoři: Weber, Jan, Rose, Justine D., Vazquez, Ana C., Winner, Dane, Margot, Nicolas, McColl, Damian J., Miller, Michael D., Quiñones-Mateu, Miguel E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679210/
https://ncbi.nlm.nih.gov/pubmed/23776513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065631
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