Resistance Mutations outside the Integrase Coding Region Have an Effect on Human Immunodeficiency Virus Replicative Fitness but Do Not Affect Its Susceptibility to Integrase Strand Transfer Inhibitors

Most studies describing phenotypic resistance to integrase strand transfer inhibitors have analyzed viruses carrying only patient-derived HIV-1 integrase genes (INT-recombinant viruses). However, to date, many of the patients on INSTI-based treatment regimes, such as raltegravir (RAL), elvitegravir...

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Detalhes bibliográficos
Main Authors: Weber, Jan, Rose, Justine D., Vazquez, Ana C., Winner, Dane, Margot, Nicolas, McColl, Damian J., Miller, Michael D., Quiñones-Mateu, Miguel E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679210/
https://ncbi.nlm.nih.gov/pubmed/23776513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065631
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