Synthesis of Indole Derived Protease-Activated Receptor 4 Antagonists and Characterization in Human Platelets

Protease activated receptor-4 (PAR4) is one of the thrombin receptors on human platelets and is a potential target for the management of thrombotic disorders. We sought to develop potent, selective, and novel PAR4 antagonists to test the role of PAR4 in thrombosis and hemostasis. Development of an e...

Full description

Saved in:
Bibliographic Details
Main Authors: Young, Summer E., Duvernay, Matthew T., Schulte, Michael L., Lindsley, Craig W., Hamm, Heidi E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679140/
https://ncbi.nlm.nih.gov/pubmed/23776495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065528
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items