Elevated Levels of CD4(+)CD25(+)FoxP3(+) T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

OBJECTIVE: Immune imbalance between regulatory T (Treg) and Th17 cells is a characteristic of systemic sclerosis (SSc). The functional heterogeneity among Treg can be elucidated by separating Treg into different subsets based on the expression of FoxP3 and CD45RA. The aim of this study was to invest...

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Detalhes bibliográficos
Main Authors: Liu, Xinjuan, Gao, Na, Li, Mengtao, Xu, Dong, Hou, Yong, Wang, Qian, Zhang, Guohua, Sun, Qiuning, Zhang, Henghui, Zeng, Xiaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679128/
https://ncbi.nlm.nih.gov/pubmed/23776439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064531
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