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Targeting autophagy for drug-induced hepatotoxicity
Autophagy is a lysosomal degradation pathway for bulk cytosolic proteins and damaged organelles, and is well known to act as a cell survival mechanism. Acetaminophen (APAP) overdose can cause liver injury in animals and humans by inducing necrosis due to mitochondrial damage. We recently found that...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2012
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3679091/ https://ncbi.nlm.nih.gov/pubmed/22441014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.19659 |
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