Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs

BACKGROUND: We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB). Specifically, PknD mediates bacillary invasion of the blood-brain barrier, which can be neutralized by specif...

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Detaylı Bibliyografya
Asıl Yazarlar: Skerry, Ciaran, Pokkali, Supriya, Pinn, Michael, Be, Nicholas A., Harper, Jamie, Karakousis, Petros C., Jain, Sanjay K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679071/
https://ncbi.nlm.nih.gov/pubmed/23776655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066310
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