Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs

BACKGROUND: We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB). Specifically, PknD mediates bacillary invasion of the blood-brain barrier, which can be neutralized by specif...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Skerry, Ciaran, Pokkali, Supriya, Pinn, Michael, Be, Nicholas A., Harper, Jamie, Karakousis, Petros C., Jain, Sanjay K.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3679071/
https://ncbi.nlm.nih.gov/pubmed/23776655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066310
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы