Amplification of DNA sequences coding for the Na,K-ATPase alpha-subunit in ouabain-resistant C+ cells.

We have studied the mechanism of cellular resistance to cardiac glycosides in C+ cells. C+ cells were resistant to ouabain and overproduced plasma membrane-bound Na,K-ATPase relative to parental HeLa cells. Overexpression of Na,K-ATPase in C+ cells correlated with increased ATPase mRNA levels and am...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Emanuel, J R, Garetz, S, Schneider, J, Ash, J F, Benz, E J, Levenson, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1986
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367801/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3023935/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.7.2476-2481.1986
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