Caricamento...
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe
A structure-activity relationship of the 3- and 6-positions of the pyrazolo[1,5-a]pyrimidine scaffold of the known BMP inhibitors dorsomorphin, 1, LDN193189, 2, and DMH1, 3, led to the identification of a potent and selective compound for ALK2 versus ALK3. The potency contributions of several 3-posi...
Salvato in:
Autori principali: | , , , , |
---|---|
Natura: | Artigo |
Lingua: | Inglês |
Pubblicazione: |
2013
|
Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677712/ https://ncbi.nlm.nih.gov/pubmed/23639540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.03.113 |
Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|