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Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome
In many individuals suspected of the common cancer predisposition Lynch syndrome, variants of unclear significance (VUS), rather than an obviously pathogenic mutations, are identified in one of the DNA mismatch repair (MMR) genes. The uncertainty of whether such VUS inactivate MMR, and therefore are...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677471/ https://ncbi.nlm.nih.gov/pubmed/23690608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220537110 |
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