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Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy

HIV-1 reverse transcription is primed by a cellular tRNAlys3 molecule that binds to the primer binding site (PBS) in the genomic RNA. An additional interaction between the tRNA molecule and the primer activation signal (PAS) is thought to regulate the initiation of reverse transcription. The mechani...

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Hlavní autoři: Beerens, Nancy, Jepsen, Mette D.E., Nechyporuk-Zloy, Volodymyr, Krüger, Asger C., Darlix, Jean-Luc, Kjems, Jørgen, Birkedal, Victoria
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677262/
https://ncbi.nlm.nih.gov/pubmed/23404895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035733.112
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