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Role of the primer activation signal in tRNA annealing onto the HIV-1 genome studied by single-molecule FRET microscopy
HIV-1 reverse transcription is primed by a cellular tRNAlys3 molecule that binds to the primer binding site (PBS) in the genomic RNA. An additional interaction between the tRNA molecule and the primer activation signal (PAS) is thought to regulate the initiation of reverse transcription. The mechani...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677262/ https://ncbi.nlm.nih.gov/pubmed/23404895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.035733.112 |
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