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FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns
Dominant mutations and mislocalization or aggregation of Fused in Sarcoma (FUS), an RNA-binding protein (RBP), cause neuronal degeneration in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), two incurable neurological diseases. However, the function of FUS in neurons...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677260/ https://ncbi.nlm.nih.gov/pubmed/23389473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.037804.112 |
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