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Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro
In vitro primary hepatocyte systems typically elicit drug induction and toxicity responses at concentrations much higher than corresponding in vivo or clinical plasma C(max) levels, contributing to poor in vitro-in vivo correlations. This may be partly due to the absence of physiological parameters...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677175/ https://ncbi.nlm.nih.gov/pubmed/23485712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00331.2012 |
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