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Determination of DNA sequence changes induced by ethyl methanesulfonate in human cells, using a shuttle vector system.

The DNA sequence changes for 54 mutations induced in human cells by the alkylating agent ethyl methanesulfonate are reported. The mutations were obtained by using a shuttle vector system with the bacterial lacI gene as the target. Of the 54 mutations obtained, 53 were G:C to A:T transitions.

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Bibliographic Details
Main Authors: Lebkowski, J S, Miller, J H, Calos, M P
Format: Artigo
Language:Inglês
Published: 1986
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC367715/
https://ncbi.nlm.nih.gov/pubmed/3023907
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