Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of Amyloid-β in Th1- and Th17-Versions of Experimental Autoimmune Encephalomyelitis

β-amyloid-42 (Aβ42) and β-amyloid-40 (Aβ40), major components of senile plaque deposits in Alzheimer’s disease (AD), are considered neurotoxic and pro-inflammatory. In multiple sclerosis (MS), Aβ42 is upregulated in brain lesions and damaged axons. Here we found, unexpectedly, that treatment with ei...

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Detalhes bibliográficos
Main Authors: Grant, Jacqueline L., Ghosn, Eliver Eid Bou, Axtell, Robert C., Herges, Katja, Kuipers, Hedwich F., Woodling, Nathan S., Andreasson, Katrin, Herzenberg, Leonard A., Herzenberg, Leonore A., Steinman, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677069/
https://ncbi.nlm.nih.gov/pubmed/22855462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3004145
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