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Amyloid fibrils activate B-1a lymphocytes to ameliorate inflammatory brain disease

Amyloid fibrils composed of peptides as short as six amino acids are therapeutic in experimental autoimmune encephalomyelitis (EAE), reducing paralysis and inflammation, while inducing several pathways of immune suppression. Intraperitoneal injection of fibrils selectively activates B-1a lymphocytes...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kurnellas, Michael Phillip, Ghosn, Eliver Eid Bou, Schartner, Jill M., Baker, Jeanette, Rothbard, Jesse J., Negrin, Robert S., Herzenberg, Leonore A., Fathman, C. Garrison, Steinman, Lawrence, Rothbard, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4679000/
https://ncbi.nlm.nih.gov/pubmed/26621719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1521206112
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