Distinctive Binding of Three Antagonistic Peptides to the Ephrin-Binding Pocket of the EphA4 Receptor

The EphA4 receptor tyrosine kinase interacts with ephrin ligands to regulate many processes, ranging from axon guidance and nerve regeneration to cancer malignancy. Thus, antagonists that inhibit ephrin binding to EphA4 could be useful for a variety of research and therapeutic applications. Here we...

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Hauptverfasser: Lamberto, Ilaria, Qin, Haina, Noberini, Roberta, Premkumar, Lakshmanane, Bourgin, Caroline, Riedl, Stefan J., Song, Jianxing, Pasquale, Elena B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677027/
https://ncbi.nlm.nih.gov/pubmed/22489865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20120408
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