ATM mutations in hereditary pancreatic cancer patients

Genome-wide sequencing identified heterozygous, constitutional, Ataxia telangiectaisa mutated (ATM) gene mutations in two kindreds with familial pancreatic cancer. Mutations segregated with disease in both kindreds and tumor analysis demonstrated LOH of the wildtype allele. Sequence analysis of an a...

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Autori principali: Roberts, Nicholas J., Jiao, Yuchen, Yu, Jun, Kopelovich, Levy, Petersen, Gloria M., Bondy, Melissa, Gallinger, Steven, Schwartz, Ann G., Syngal, Sapna, Cote, Michele L., Axilbund, Jennifer, Schulick, Richard, Ali, Syed Z., Eshleman, James R., Velculescu, Victor, Goggins, Michael, Vogelstein, Bert, Papadopoulous, Nikolas, Hruban, Ralph H., Kinzler, Kenneth W., Klein, Alison P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676748/
https://ncbi.nlm.nih.gov/pubmed/22585167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0194
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