E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha

CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for the first time we demonstrate that E6AP, an E3 ubiquitin ligase inhibits adipocyte differentiation in 3T3-L1 cells as revealed by reduced lipid staining with oil red. Knock...

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Autores principales: Pal, Pooja, Lochab, Savita, Kanaujiya, Jitendra Kumar, Kapoor, Isha, Sanyal, Sabyasachi, Behre, Gerhard, Trivedi, Arun Kumar
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676453/
https://ncbi.nlm.nih.gov/pubmed/23762344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065330
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