Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment

Synaptic vesicle exocytosis is mediated by the vesicular Ca(2+)-sensor synaptotagmin-1. Synaptotagmin-1 interacts with the SNARE protein syntaxin-1A and with acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PIP2). However, it is unclear how these interactions contribute to trigger...

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Main Authors: Honigmann, Alf, van den Bogaart, Geert, Iraheta, Emilio, Risselada, H. Jelger, Milovanovic, Dragomir, Mueller, Veronika, Müllar, Stefan, Diederichsen, Ulf, Fasshauer, Dirk, Grubmüller, Helmut, Hell, Stefan W., Eggeling, Christian, Kühnel, Karin, Jahn, Reinhard
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676452/
https://ncbi.nlm.nih.gov/pubmed/23665582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2570
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