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Neuromyelitis optica: Aquaporin-4 based pathogenesis mechanisms and new therapies
Neuromyelitis optica (NMO) is an autoimmune ‘aquaporinopathy’ of the central nervous system that causes inflammatory demyelinating lesions primarily in spinal cord and optic nerve, leading to paralysis and blindness. NMO lesions show loss of aquaporin-4 (AQP4), GFAP and myelin, infiltration of granu...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3676174/ https://ncbi.nlm.nih.gov/pubmed/22713791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2012.06.013 |
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