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Human Immunoglobulin G Reduces the Pathogenicity of Aquaporin-4 Autoantibodies in Neuromyelitis Optica
Neuromyelitis optica (NMO) pathogenesis involves binding of anti-aquaporin-4 (AQP4) autoantibodies (NMO-IgG) present in serum to AQP4 on astrocytes, which causes complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). Human immunoglobulin G (hIgG) is effective fo...
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| Publicado no: | Exp Neurol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291172/ https://ncbi.nlm.nih.gov/pubmed/24636863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2014.03.004 |
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