Persistent Enteric Murine Norovirus Infection Is Associated with Functionally Suboptimal Virus-Specific CD8 T Cell Responses

Norovirus (NV) gastroenteritis is a major contributor to global morbidity and mortality, yet little is known about immune mechanisms leading to NV control. Previous studies using the murine norovirus (MNV) model have established a key role for T cells in MNV clearance. Despite these advances, import...

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Detalhes bibliográficos
Main Authors: Tomov, Vesselin T., Osborne, Lisa C., Dolfi, Douglas V., Sonnenberg, Gregory F., Monticelli, Laurel A., Mansfield, Kathleen, Virgin, Herbert W., Artis, David, Wherry, E. John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3676130/
https://ncbi.nlm.nih.gov/pubmed/23596300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03389-12
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