Factors That Limit Positron Emission Tomography Imaging of P-Glycoprotein Density at the Blood–Brain Barrier

[Image: see text] Efflux transporters located at the blood–brain barrier, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), regulate the passage of many drugs in and out of the brain. Changes in the function and density of these proteins, in particular P-gp, may play a role...

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Bibliographische Detailangaben
Hauptverfasser: Kannan, Pavitra, Pike, Victor W., Halldin, Christer, Langer, Oliver, Gottesman, Michael M., Innis, Robert B., Hall, Matthew D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675842/
https://ncbi.nlm.nih.gov/pubmed/23597242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400011g
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