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Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

There is a growing need for highly accurate in silico and in vitro predictive models to facilitate drug discovery and development. Results from in vitro permeation studies across the Caco-2 cell monolayer are commonly used for drug permeability screening in industry and are also accepted as a surrog...

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מידע ביבליוגרפי
Main Authors: Larregieu, Caroline A., Benet, Leslie Z.
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer US 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675726/
https://ncbi.nlm.nih.gov/pubmed/23344793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9456-8
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