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A Novel p53 Mutant Found in Iatrogenic Urothelial Cancers Is Dysfunctional and Can Be Rescued by a Second-site Global Suppressor Mutation

Exposure to herbal remedies containing the carcinogen aristolochic acid (AA) has been widespread in some regions of the world. Rare A→T TP53 mutations were recently discovered in AA-associated urothelial cancers. The near absence of these mutations among all other sequenced human tumors suggests tha...

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Библиографические подробности
Главные авторы: Odell, Adam F., Odell, Luke R., Askham, Jon M., Alogheli, Hiba, Ponnambalam, Sreenivasan, Hollstein, Monica
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675604/
https://ncbi.nlm.nih.gov/pubmed/23612969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.443168
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