Down-regulation of Wild-type p53-induced Phosphatase 1 (Wip1) Plays a Critical Role in Regulating Several p53-dependent Functions in Premature Senescent Tumor Cells

Premature or drug-induced senescence is a major cellular response to chemotherapy in solid tumors. The senescent phenotype develops slowly and is associated with chronic DNA damage response. We found that expression of wild-type p53-induced phosphatase 1 (Wip1) is markedly down-regulated during pers...

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Главные авторы: Crescenzi, Elvira, Raia, Zelinda, Pacifico, Francesco, Mellone, Stefano, Moscato, Fortunato, Palumbo, Giuseppe, Leonardi, Antonio
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675561/
https://ncbi.nlm.nih.gov/pubmed/23612976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.435149
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