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The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.

In the DNAs of all Ph1-positive chronic myelocytic leukemia patients studied to date, a breakpoint on chromosome 22 (the Ph1 chromosome) can be demonstrated with a probe from the bcr (breakpoint cluster region). Although the K562 cell line was established from cells of a chronic myelocytic leukemia...

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Udgivet i:Mol Cell Biol
Principais autores: Grosveld, G, Verwoerd, T, van Agthoven, T, de Klein, A, Ramachandran, K L, Heisterkamp, N, Stam, K, Groffen, J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC367552/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3023859/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.6.2.607-616.1986
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