Tumor suppressor p53 plays a key role in induction of both tristetraprolin and let-7 in human cancer cells

Tristetraprolin (TTP) and let-7 microRNA exhibit suppressive effects on cell growth through down-regulation of oncogenes. Both TTP and let-7 are often repressed in human cancers, thereby promoting oncogenesis by derepressing their target genes. However, the precise mechanism of this repression is un...

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Main Authors: Lee, Ji Young, Kim, Hyo Jeong, Yoon, Nal Ae, Lee, Won Hyeok, Min, Young Joo, Ko, Byung Kyun, Lee, Byung Ju, Lee, Aran, Cha, Hee Jeong, Cho, Wha Ja, Park, Jeong Woo
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675463/
https://ncbi.nlm.nih.gov/pubmed/23595149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt222
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