Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

The observation that long tracts of RNA are associated with replicating molecules of mitochondrial DNA (mtDNA) suggests that the mitochondrial genome of mammals is copied by an unorthodox mechanism. Here we show that these RNA-containing species are present in living cells and tissue, based on inter...

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Bibliographic Details
Main Authors: Reyes, Aurelio, Kazak, Lawrence, Wood, Stuart R., Yasukawa, Takehiro, Jacobs, Howard T., Holt, Ian J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675460/
https://ncbi.nlm.nih.gov/pubmed/23595151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt196
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