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Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans

BACKGROUND: One of the key genes that regulate human brain size, MCPH1 has evolved under strong Darwinian positive selection during the evolution of primates. During this evolution, the divergence of MCPH1 protein sequences among primates may have caused functional changes that contribute to brain e...

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Detalhes bibliográficos
Main Authors: Shi, Lei, Li, Ming, Lin, Qiang, Qi, Xuebin, Su, Bing
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674976/
https://ncbi.nlm.nih.gov/pubmed/23697381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-11-62
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