Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells: A Nondirected Metabolomic Study

We studied the influence of PON1 on metabolic alterations induced by oxidized LDL when incubated with endothelial cells. HUVEC cells were incubated with native LDL, oxidized LDL, oxidized LDL plus HDL from wild type mice, and oxidized LDL plus HDL from PON1-deficient mice. Results showed alterations...

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Autors principals: García-Heredia, Anabel, Marsillach, Judit, Rull, Anna, Triguero, Iris, Fort, Isabel, Mackness, Bharti, Mackness, Michael, Shih, Diana M., Joven, Jorge, Camps, Jordi
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674710/
https://ncbi.nlm.nih.gov/pubmed/23766557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/156053
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