Decreased paraoxonase-1 activity is associated with alterations of high-density lipoprotein particles in chronic liver impairment

BACKGROUND: Paraoxonase-1 (PON1), a lactonase synthesized by the liver, circulates in blood bound to high-density lipoproteins (HDL). This enzyme is thought to degrade oxidized phospholipids and play an important role in the organism's antioxidant and anti-inflammatory system. Chronic liver dis...

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Bibliografiske detaljer
Main Authors: Marsillach, Judit, Aragonès, Gerard, Mackness, Bharti, Mackness, Michael, Rull, Anna, Beltrán-Debón, Raúl, Pedro-Botet, Juan, Alonso-Villaverde, Carlos, Joven, Jorge, Camps, Jordi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877049/
https://ncbi.nlm.nih.gov/pubmed/20470383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-511X-9-46
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