Paraoxonase-1 Inhibits Oxidized Low-Density Lipoprotein-Induced Metabolic Alterations and Apoptosis in Endothelial Cells: A Nondirected Metabolomic Study

We studied the influence of PON1 on metabolic alterations induced by oxidized LDL when incubated with endothelial cells. HUVEC cells were incubated with native LDL, oxidized LDL, oxidized LDL plus HDL from wild type mice, and oxidized LDL plus HDL from PON1-deficient mice. Results showed alterations...

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Detalhes bibliográficos
Main Authors: García-Heredia, Anabel, Marsillach, Judit, Rull, Anna, Triguero, Iris, Fort, Isabel, Mackness, Bharti, Mackness, Michael, Shih, Diana M., Joven, Jorge, Camps, Jordi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674710/
https://ncbi.nlm.nih.gov/pubmed/23766557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/156053
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