Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes

INTRODUCTION: Extracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory cytokine interleukin-1 beta (IL-1β) functions in ECM degradation and prevents ECM synthesis by down-regulating the key transcription factor, Sox9, and consequently inhibiti...

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Bibliographische Detailangaben
Hauptverfasser: Dai, Linghui, Zhang, Xin, Hu, Xiaoqing, Zhou, Chunyan, Ao, Yingfang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674628/
https://ncbi.nlm.nih.gov/pubmed/23227940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4114
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