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Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes
INTRODUCTION: Extracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory cytokine interleukin-1 beta (IL-1β) functions in ECM degradation and prevents ECM synthesis by down-regulating the key transcription factor, Sox9, and consequently inhibiti...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674628/ https://ncbi.nlm.nih.gov/pubmed/23227940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4114 |
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