The RNA kinase CLP1 links tRNA metabolism to progressive motor neuron loss

CLP1 is the first discovered mammalian RNA kinase. However, its in vivo function has been entirely elusive. We have generated kinase-dead Clp1 (Clp1(K/K)) mice which exhibit a progressive loss of spinal motor neurons associated with axonal degeneration in peripheral nerves, denervation of neuromuscu...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Hanada, Toshikatsu, Weitzer, Stefan, Mair, Barbara, Bernreuther, Christian, Wainger, Brian J., Ichida, Justin, Hanada, Reiko, Orthofer, Michael, Cronin, Shane J, Komnenovic, Vukislav, Minis, Adi, Sato, Fuminori, Mimata, Hiromitsu, Yoshimura, Akihiko, Tamir, Ido, Rainer, Johannes, Kofler, Reinhard, Yaron, Avraham, Eggan, Kevin C., Woolf, Clifford J., Glatzel, Markus, Herbst, Ruth, Martinez, Javier, Penninger, Josef M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674495/
https://ncbi.nlm.nih.gov/pubmed/23474986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11923
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky