GADD45β mediates p53 protein degradation via Src/PP2A/MDM2 pathway upon arsenite treatment

Growth arrest and DNA-damage-inducible, beta (GADD45β) has been reported to inhibit apoptosis via attenuating c-Jun N-terminal kinase (JNK) activation. We demonstrated here that GADD45β mediated its anti-apoptotic effect via promoting p53 protein degradation following arsenite treatment. We found th...

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Autori principali: Yu, Y, Huang, H, Li, J, Zhang, J, Gao, J, Lu, B, Huang, C
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674369/
https://ncbi.nlm.nih.gov/pubmed/23681232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.162
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